In some cases switching back to the cotli game window by clicking, I coincidentally hit certain text labels, which seem to get focus then, so none of the hotkeys work anymore, unless I click elsewhere. That happens i.e. on "chests", "rubies", "idols", "total", "achievements", the rubies amount count or the starter pack text labels.

This bug had bothered me once in a while for months/years now. Finally found it