Was going strong until boss at 1585... after easily wiping the little guys, boss came out and took zero damage (not even a progress bar) until wiping my party. Still happens after reloading game. Is this some sort of area limit? Thanks

To add a little more clarification to Erika's description, the DPS cap only affects YOUR crusaders. So once you hit e308, your damage can't go any higher, and that's the point the game considers "infinity". That means that enemies with e308 HEALTH become unkillable due to the game registering them as "infinite health". If your DPS is 5.0e307, then it will take 1 full second for you to kill enemies with 5.0e307 health, but then in another area or two, it might take you TWO seconds to kill an enemy, but 5.0e307 times 2 would be 1.0e308. That means that even if YOU haven't hit the DPS cap, monster health has. Any time you are not killing monsters within 1 second, it means they have higher health than your DPS, so monster health can possibly reach the cap before your DPS can.

Once you raise the DPS cap, the same enemies will not be considered "infinite health" because their health isn't at the new DPS cap anymore.

Just being more clear since "Why can't I beat this immortal enemy?" doesn't seem to be properly answered by "Your damage isn't high enough." Why would MY damage affect an enemy that takes NO damage? Because video game logic lol But it could be confusing if not fully explained anyway.

Ghostbeard's Greed has the first DPS cap increase, "To Infinity and Beyond!", a tier-3 objective. Completing that objective will increase the DPS cap to e400. The second (and latest, currently) one is in Ready Player Two, "Bullet Hell", another tier-3 objective, and will further raise the cap to e600, the current absolute cap.