5.41e216. But I didn't use buffs to increase that, and the actual damage per second is much higher 'cause I have the Bush Whacker hitting for 15 times my DPS with a single click (and I'm clicking 40 times per second), and that does NOT include criticals (I have over 100% crit chance, and +1140% crit damage). Factoring in these things, my actual DPS (not what it's shown at the top, but the damage I end up doing) is closer to 4e220

area 1004, highest dps 6.38e195 in some event free play.
as a general guideline for most objectives if you divide the area you want to reach by 5.2 you get the exponent of the dps you need to reach that area. but some objectives that factor of 5.2 is not that , it might be 4.0, depends on the objective

My DPSer is Sal the Merman largely due to Boggins' effect, but also because I have all of his golden legendaries. Highest DPS ever was 6.76e204 but I haven't really pushed in ages. In terms of semi-pushing a few extra areas with a pure-DPS formation, Merci is where a lot of my damage comes from because I deal 90% of my damage to every enemy on screen per enemy on screen, up to 900%, meaning that having just 5 enemies on screen leads to me dealing 4.5x my DPS to all enemies at once. AoE damage means a hell of a lot more than pure DPS when you're pushing end-run areas since beating one enemy before it reaches you is less important than beating a WAVE of enemies before they reach you.

I typically reach area 1050-ish, but, again, that is without really pushing. No clicking or buffs.

my favorite is ilsa.
on the gardeners event freeplay i hit area 1200 with e233 dps.
my best buffer is pete with his chicken at level 8 ;)